1, 5, 7-Triazabicyclo [4.4. 0] dec-5-ene (TBD) catalyzed Michael reactions

W Ye, J Xu, CT Tan, CH Tan

Index: Ye, Weiping; Xu, Junye; Tan, Chin-Tong; Tan, Choon-Hong Tetrahedron Letters, 2005 , vol. 46, # 40 p. 6875 - 6878

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Citation Number: 99

Abstract

1, 5, 7-Triazabicyclo [4.4. 0] dec-5-ene (TBD), a bicyclic guanidine base, has been found to be an excellent catalyst for Michael and Michael-type reactions. A wide variety of Michael donors and acceptors can participate in these reactions using 10–20mol% of TDB. These reactions are mild, fast, easy to perform, produce excellent yields and can occur in several solvents without the need for strictly anhydrous conditions.