Tetrahedron letters

Regioselective carbon-carbon bond formation at C2 of 1, 3-thiazole by reaction of n-ethoxycarbonylthiazolium chloride with C-nucleophiles

A Dondoni, T Dall'Occo, G Fantin, M Fogagnolo…

Index: Dondoni, Alessandro; Dall'Occo, Tiziano; Fantin, Giancarlo; Fogagnolo, Marco; Medici, Alessandro Tetrahedron Letters, 1984 , vol. 25, # 33 p. 3633 - 3636

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Citation Number: 10

Abstract

Abstract N-Ethoxycarbonylthiazolium chloride generated in situ from 1, 3-thiazole and ethyl chloroformate, treated with lithium carbanions of esters, Grignard reagents, silyl enol ethers and esters, undergo nucleophilic addition at C 2 affording the corresponding 2-substituted ...