Chemical synthesis and molecular pharmacology of hydroxylated 1-(1-phenylcyclohexyl) piperidine derivatives

…, B Chiche, R Goudal, P Geneste, J Vignon…

Index: Kamenka; Chiche; Goudal; Geneste; Vignon; Vincent; Lazdunski Journal of Medicinal Chemistry, 1982 , vol. 25, # 4 p. 431 - 435

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Citation Number: 53

Abstract

Results Chemical Synthesis. The different molecules that have been synthesized are presented in Table I. Phenolic Compounds 1-3. It was not possible to synthesize these three compounds from the amino derivatives obtained by hydrogenation of the nitro homologues as previously described by Kalir et al. 13 because of the almost exclusive metanitration of PCP. 14 The compound previously identified as 1 by Kalir et al. 13 is probably compound ...