Halogenation of Imidazo [4, 5-b] pyridin-2-one Derivatives

…, KY Lopatinskaya, NN Smolyar, SV Gres'ko

Index: Yutilov; Lopatinskaya; Smolyar; Gres'ko Russian Journal of Organic Chemistry, 2005 , vol. 41, # 4 p. 575 - 579

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Citation Number: 2

Abstract

Abstract Chlorination and bromination of 2, 3-dihydro-1 H-imidazo [4, 5-b] pyridin-2-one and its N-methyl-substituted derivatives in acetic acid at 90–95° C leads to formation of the corresponding 5, 6-dichloro (dibromo)-2, 3-dihydro-1 H-imidazo [4, 5-b] pyridin-2-ones. Iodination of the same substrates with ICl under analogous conditions yields 6-iodo derivatives. Chlorination of 6-iodo-1, 3-dimethyl-2, 3-dihydro-1 H-imidazo [4, 5-b] pyridin-2 ...