Direct intramolecular arylation of aldehydes promoted by reaction with IPy2BF4/HBF4: Synthesis of benzocyclic ketones

J Barluenga, M Trincado, E Rubio…

Index: Barluenga, Jose; Trincado, Monica; Rubio, Eduardo; Gonzalez, Jose M. Angewandte Chemie - International Edition, 2006 , vol. 45, # 19 p. 3140 - 3143

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Citation Number: 75

Abstract

IPy2BF4 was increased, the yield of 4 was not improved. However, the use of more electrophilic conditions gave better results (Table 1, entry 6). For entries 1–5, 3 was added to a cooled solution that contained the iodinating reagent and the acid. However, in the case of entry 6, a different experimental protocol was adopted. First, the iodinating agent and the acid were mixed at À808C, and the pyridinium salts generated in the neutralization were ...

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