Tetrahedron Letters

A one-pot synthesis of α-formyl-α-allylacetates via nucleophilic catalysis

W Chung, P Lindovska, JE Camp

Index: Chung, William; Lindovska, Petra; Camp, Jason E. Tetrahedron Letters, 2011 , vol. 52, # 50 p. 6785 - 6787

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Citation Number: 4

Abstract

A step-economical one-pot nucleophilic catalysis/thermal Claisen-rearrangement protocol for the direct synthesis of α-formyl-α-allylacetates from allylic alcohols and activated alkynes has been developed. The product α-formyl-α-allylacetates were further reacted in situ to give either protected enol ethers or β-hydroxy-4-pentenoates.

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