Antioxidative properties of nitroxyl radicals and hydroxyamines in reactions with triplet and deaminated kynurenine

VV Yan'shole, IA Kirilyuk, IA Grigor'ev…

Index: Yan'shole; Kirilyuk; Grigor'ev; Morozov; Tsentalovich Russian Chemical Bulletin, 2010 , vol. 59, # 1 p. 66 - 74

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Citation Number: 9

Abstract

Abstract The reactions of triplet kynurenine and 4-(2-aminophenyl)-4-oxocrotonic acid, formed upon the thermal decomposition of kynurenine, with nitroxyl radicals and cyclic N- hydroxylamines were studied. Nitroxyl radicals were found to quench efficiently the triplet state of kynurenine (rate constant 3–6·. 10 8 L mol-1 s-1). The quenching proceeds via the spin-exchange mechanism and affords no new products. Neither nitroxyl radicals, nor ...