Tetrahedron letters

InBr 3–Et 3 N promoted alkynylation of aldehydes and N, O-acetals under mild conditions: facile and simple preparation of propargylic alcohols and amines

N Sakai, M Hirasawa, T Konakahara

Index: Sakai, Norio; Hirasawa, Maki; Konakahara, Takeo Tetrahedron Letters, 2003 , vol. 44, # 22 p. 4171 - 4174

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Citation Number: 52

Abstract

The use of a novel InBr3–Et3N reagent system to promote addition reactions of 1-alkynes not only with a variety of aromatic or bulky aliphatic aldehydes but also with N, O-acetals is described. The corresponding propargylic alcohols or amines are produced in good to excellent yields.

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