Bioorganic & medicinal chemistry

Thiahomoisocitrate: a highly potent inhibitor of homoisocitrate dehydrogenase involved in the α-aminoadipate pathway

T Yamamoto, T Eguchi

Index: Yamamoto, Takashi; Eguchi, Tadashi Bioorganic and Medicinal Chemistry, 2008 , vol. 16, # 6 p. 3372 - 3376

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Citation Number: 9

Abstract

Homoisocitrate dehydrogenase is involved in the α-aminoadipate pathway of l-lysine biosynthesis in higher fungi such as yeast and human pathogenic fungi. This enzyme catalyzes the oxidative decarboxylation of (2R, 3S)-homoisocitrate into 2-ketoadipate using NAD+ as a coenzyme. A series of aza-, oxa-, and thia-analogues of homoisocitrate was designed and synthesized as an inhibitor for homoisocitrate dehydrogenase. Among them ...