Synthesis and Absolute Configuration of (−)??Neuchromenin, a Neurotrophic Metabolite of Eupenicillium javanicum var. meloforme, and Its Enantiomer

Y Tanada, K Mori

Index: Tanada, Yoshihisa; Mori, Kenji European Journal of Organic Chemistry, 2001 , # 10 p. 1963 - 1966

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Citation Number: 6

Abstract

Abstract Both the enantiomers of neuchromenin 1 (2, 3-dihydro-8, 9-dihydroxy-2-methyl-4H, 5H-pyrano [3, 2-c][1] benzopyran-4-one) were synthesized starting from the enantiomers of ethyl 3-hydoxybutanoate (7). The naturally occurring (−)-neuchromenin, a neurotrophic metabolite of Eupenicillium javanicum var. meloforme, was shown to be (S)-1.