Kinetic and mechanistic studies on the hydrolysis and photodegradation of diazepam and alprazolam

…, RG De Waisbaum, NS Nudelman

Index: Cabrera, C. Gallardo; Goldberg De Waisbaum; Nudelman, N. Sbarbati Journal of Physical Organic Chemistry, 2005 , vol. 18, # 2 p. 156 - 161

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Citation Number: 14

Abstract

Abstract The corresponding o-aminobenzophenones are usually reported as the main degradation products in the hydrolysis of 1, 4-benzodiazepinones. Nevertheless, in previous studies of diazepam (DZ) in acidic aqueous medium we isolated and characterized seven unexpected degradation products. Kinetic measurements under several reaction conditions shed some light on the mechanisms of the complex reactions that are taking place, and ...

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