Substituted (pyrroloamino) pyridines: Potential agents for the treatment of Alzheimer's disease

L Davis, GE Olsen, JT Klein, KJ Kapples…

Index: Davis, Larry; Olsen, Gordon E.; Klein, Joseph T.; Kapples, Kevin J.; Huger, Francis P.; et al. J. Med. Chem., 1996 , vol. 39, # 2 p. 582 - 587

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Citation Number: 14

Abstract

A novel series of substituted (pyrroloamino) pyridines was synthesized, and the compounds were evaluated for cholinomimetic-like properties in vitro (inhibition of [3H] quinuclidinyl benzilate binding) and in vivo (reversal of scopolamine-induced dementia) as potential agents for the treatment of Alzheimer's disease. Compounds displaying significant activity were more broadly evaluated, which revealed the presence of a desirable adrenergic ...