The First One??Pot, Solvent??Free, Microwave??Accelerated, Three??Component Synthesis of Spirothiazolidin??4??ones via Staudinger/Aza??Wittig Coupling/Cyclization

A Ponnuswamy, P Shanmugavelan…

Index: Ponnuswamy, Alagusundaram; Shanmugavelan, Poovan; Nagarajan, Sangaraiah; Sathishkumar, Murugan Helvetica Chimica Acta, 2012 , vol. 95, # 6 p. 922 - 928

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Citation Number: 5

Abstract

Abstract An efficient and rapid, solvent-free, microwave-accelerated, one-pot, three- component protocol for the synthesis of spirothiazolidin-4-ones from organic azides is reported for the first time via Staudinger/aza-Wittig coupling/cyclization. The solvent-free approach overcomes the limitations associated with the prevailing solution-phase methodologies in the case of amines. In particular, its novelty is that it eradicates the vital ...

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