p-Substituted benzyl Hydroxybisphosphonates: Synthesis and Hydrolysis

I Mallard, JM Benech, M Lecouvey…

Index: Mallard, Isabelle; Benech, Jean-Marc; Lecouvey, Marc; Leroux, Yves Phosphorus, Sulfur and Silicon and Related Elements, 2000 , vol. 162, p. 15 - 23

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Citation Number: 13

Abstract

Several hydroxybisphosphonate benzyl esters have been synthesized for study. The effect of the benzyl substituent on the acidic hydrolysis of the phosphonic esters has also been studied. ... Keywords: Hydroxybisphosphonate; p-substituted benzyl esters; acidic hydrolysis ... Hydroxybisphosphonates are pyrophosphate analogs in which the oxygen bridge has been replaced by carbon, and diverse side chains have gener- ated a large family of ...