Synthesis and bioevaluation of novel 4-aminoquinoline-tetrazole derivatives as potent antimalarial agents

…, P Agarwal, K Srivastava, S RajaKumar, SK Puri…

Index: Pandey, Shashi; Agarwal, Pooja; Srivastava, Kumkum; RajaKumar; Puri, Sunil K.; Verma, Pravesh; Saxena; Sharma, Abhisheak; Lal, Jawahar; Chauhan, Prem M. S. European Journal of Medicinal Chemistry, 2013 , vol. 66, p. 69 - 81

Full Text: HTML

Citation Number: 28

Abstract

Abstract A series of novel tetrazole derivatives of 4-aminoquinoline were synthesized and screened for their antimalarial activities against both chloroquine-senstive (3D7) and chloroquine-resistant (K1) strains of Plasmodium falciparum as well as for cytotoxicity against VERO cell lines. Most of the synthesized compounds exhibited potent antimalarial activity as compared to chloroquine against K1-strain. Compounds with significant in vitro ...