Synthesis and characterization of biodegradable copolyesters and copolyanhydrides prepared from fumaric and succinic acid trimers and oligomers

S Ben??Shabat, O Elmalak, A Nyska…

Index: Ben-Shabat, Shimon; Elmalak, Omar; Nyska, Abraham; Domb, Abraham J. Israel Journal of Chemistry, 2005 , vol. 45, # 4 p. 411 - 420

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Citation Number: 3

Abstract

Abstract A series of new biodegradable copolymers and copolyanhydrides built of trimers of fumaric and succinic acid and propylene glycol, covering a wide range of compositions, were prepared and characterized for use as drug carriers. The polymers were found to degrade within a period of weeks. Polyanhydrides loaded with ibuprofen as a model drug released the drug for a period of one week, while the polyesters released the drug for ...