Journal of the Iranian Chemical Society

Microwave promoted improved regioselective synthesis of 1H, 3H, 6H [2] benzopyrano [4, 3-d] pyrimidine-2, 4-diones by radical cyclisation

PK Basu, A Ghosh

Index: Basu, Pradipta Kumar; Ghosh, Amrita Journal of the Iranian Chemical Society, 2013 , vol. 10, # 1 p. 55 - 62

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Abstract

Abstract In this work, two new effective methodologies have been adopted for the preparation of 5-(2′-bromobenzyloxy) pyrimidine-2, 4-diones 6 (a–k). In the first methodology, 5-hydroxy uracils 4 (a–f) were alkylated with 2-bromobenzyl bromide 5a or 2- bromo-5-methoxy benzyl bromide 5b under phase transfer catalysis condition using lithium hydroxide/tetrabutyl ammonium bromide in N, N-dimethylformamide at 45° C, and in the ...