Candida rugosa lipase: enantioselectivity enhancements in organic solvents

RA Persichetti, JJ Lalonde, CP Govardhan, NK Khalaf…

Index: Persichetti, Rose A.; Lalonde, Jim J.; Govardhan, Chandrika P.; Khalaf, Nazer K.; Margolin, Alexey L. Tetrahedron Letters, 1996 , vol. 37, # 36 p. 6507 - 6510

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Citation Number: 52

Abstract

Chiral resolutions of carboxylic acids (1–3) and alcohol (4) were carried out through esterification or transesterification in organic solvents using cross-linked enzyme crystals (CLEC®) of Candida rugosa lipase (CRL). Comparison of these results with those of crude CRL reveal significant differences. As was seen in resolution through hydrolysis, 1 a marked improvement in enantioselectivity is realized with the CLEC. Additionally, the stability ...