Synthesis of new synthons for organofluorine compounds from halothane containing sulfur functional groups

M Kato, K Maeda, K Sato, M Omote, A Ando…

Index: Kato, Makoto; Maeda, Kensuke; Sato, Kazuyuki; Omote, Masaaki; Ando, Akira; Kumadaki, Itsumaro Chemical and Pharmaceutical Bulletin, 2000 , vol. 48, # 5 p. 683 - 686

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Citation Number: 5

Abstract

To develop new synthons for the syntheses of organofluorine compounds, the treatment of Halothane, 2-bromo-2-chloro-1, 1, 1-trifluoroethane,(1) with 4-methylbenzenethiol (2) in the presnce of sodium hydride gave 1-chloro-2, 2, 2-trifluoroethyl 4-methylphenyl sulfide (3), which was oxidized with m-chloroperbenzoic acid (m-CPBA) to the corresponding sulfoxide (4) and sulfone (5). Reaction of 3 and 5 with allyltributyltin in the presence of 2, 2'-azobis ( ...