Tetrahedron Letters

Nickel-catalyzed cross-coupling reaction of acetylenic sulfones with alkynyl Grignard reagents: a facile method for the preparation of unsymmetrical 1, 3-diynes

K Fang, M Xie, Z Zhang, P Ning, G Shu

Index: Fang, Kuang; Xie, Meihua; Zhang, Zhannan; Ning, Peng; Shu, Guanying Tetrahedron Letters, 2013 , vol. 54, # 29 p. 3819 - 3821

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Citation Number: 8

Abstract

The cross-coupling reaction of acetylenic sulfones with acetylenic Grignard reagents was realized by using Ni (acac) 2 as catalyst to afford unsymmetrical 1, 3-diynes under mild conditions without homocoupling byproducts. By using this method, 1, 4-diaryl-1, 3-diynes could be obtained in moderate to good yields (59–83%), whereas, the yields for alkyl substituted 1, 3-diynes are lower (30–54%).