Synthesis of the α-Tocopheramine-15N Model Compound 2, 2, 5, 7, 8-Pentamethyl-6-chromanylamine-15N

S Bohmdorfer, L Gille, T Rosenau

Index: Boehmdorfer, Stefan; Gille, Lars; Rosenau, Thomas Letters in Organic Chemistry, 2010 , vol. 7, # 4 p. 335 - 337

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Abstract

2, 2, 5, 7, 8-Pentamethyl-6-chromanylamine-15N was prepared by condensation of ZnCl2- catalyzed condensation of 2, 3, 5-trimethylphenol with isoprene, followed by conversion of the resulting chroman into the 6-nitro-derivative and further reduction to the title compound, which possesses a 2-methyl group instead of the isoprenoid side chain of tocopherols and tocopheramines. Tocopheramines and their short-chain analogues are current targets in ...