Syntheses of psoralen analogues and evaluation of their inhibition of epidermal growth factor binding

ND Heindel, JMAM Van Dongen…

Index: Heindel; Van Dongen; Sachais; Phillips; Gallo; Laskin Journal of Pharmaceutical Sciences, 1991 , vol. 80, # 7 p. 686 - 689

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Citation Number: 8

Abstract

Abstract An exchange hydrogenation reaction on trioxsalen yields two isomeric dihydro analogues for which a combined HPLC-supercritical fluid chromatography method supplies purified materials. These reduced compounds and a related benzodipyranone are biologically active and inhibit the binding of epidermal growth factor on HeLa cells to an even greater extent than trioxsalen. This observation suggests a non-DNA target may play ...