Synthesis and hypocholesterolemic activity of alkylidenedithio bisphenols

MB Neuworth, RJ Laufer, JW Barnhart…

Index: Neuworth,M.B. et al. Journal of Medicinal Chemistry, 1970 , vol. 13, p. 722 - 725

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Citation Number: 38

Abstract

The synthesis and seruni cholesterol lowering properties of a new class of alkylidenedithio bisphenols alld re-lated compounds are discussed. Maximum act, ivity is shown by 4, 4'- (isopropylidenedithio) bis (2, 6-di-t-buiyl-phenol).. 4 few other members of the class show moderat% e to good activity and these are produced by substitn-tion of a RIe group or an GPr group for one t-Bu group in the phenolic nucleus, or substitution of Et for RIe iri the ...