A New One-Pot, Three-Component Synthesis of 2, 3, 5-Substituted or Annulated-6-(Methylthio) pyridines

AK Yadav, SKS Yadav, I Siddiqui, S Peruncheralathan…

Index: Yadav; Siddiqui; Peruncheralathan; Ila; Junjappa Synlett, 2008 , # 17 p. 2674 - 2680

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Abstract

Abstract A new one-pot, three-component synthesis of 2, 3, 5-substituted (or 2, 3-annulated)- 6-(methylthio) pyridines by reacting acyclic or cyclic active methylene ketones, ammonium acetate, and bis (methylthio) acrolein (1) or its 2-phenyl analogue 8 (as 3-carbon-1, 3- biselectrophilic components) in the presence of either AcOH-TFA (4: 1) or ZnBr 2 (or ZnI 2) catalysts has been reported.