Synlett

Water-mediated multicomponent reaction: a facile and efficient synthesis of multisubstituted thiazolidine-2-thiones

SF Gan, JP Wan, YJ Pan, CR Sun

Index: Gan, Shi-Feng; Wan, Jie-Ping; Pan, Yuan-Jiang; Sun, Cui-Rong Synlett, 2010 , # 6 p. 973 - 975

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Citation Number: 15

Abstract

Abstract A facile, efficient, and green method for the synthesis of multisubstituted thiazolidine- 2-thione derivatives via a three-component reaction of amine, carbon disulfide, and α- bromoketone is described. By using water as the reaction medium, the reaction proceeds smoothly to give corresponding products in good to excellent yields.