Synthesis and biological evaluation of new carbohydrate-substituted indenoisoquinoline topoisomerase I inhibitors and improved syntheses of the experimental …

DE Beck, K Agama, C Marchand…

Index: Kahn Chemische Berichte, 1885 , vol. 18, p. 3365

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Citation Number: 24

Abstract

... Volume: Page: ... Within the indolocarbazole class, glycosylation is a critical feature for Top1 inhibitory activity, and its absence severely compromises potency.(18, 19) Attachment of a carbohydrate moiety to the indenoisoquinoline system has the potential to ...