The Journal of Organic Chemistry

5-Arylthiopyrimidines. III. Cyclization of 4-Hydroxy Derivatives to 10H-Pyrimido [5, 4-b][1, 4] benzothiazines (1, 3-Diazaphenothiazines) 1

B Roth, LA Schloemer

Index: Roth,B.; Schloemer,L.A. Journal of Organic Chemistry, 1963 , vol. 28, p. 2659 - 2672

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Citation Number: 16

Abstract

4-Hydroxy-5-bromopyrimidines containing a variety of electron-releasing substituents in the 2-and 6-positions react readily with 0-aminothiophenoxide ion to produce 4-hydroxy-5-(o- aminoarylthio) pyrimidines. The products cyclize with ease by warming in dilute aqueous or alcoholic acid, to produce lOH-pyrimid0 [5, 4-b][1, 4]-benzothiazines. The parent compound of this new ring system was prepared from the 2-hydroxy derivative by ...