Tetrahedron

Three-component reaction for the C2-functionalization of 1-substituted imidazoles with acetylenic ketones and isocyanates

Y Shen, S Cai, C He, X Lin, P Lu, Y Wang

Index: Shen, Yang; Cai, Shuying; He, Chi; Lin, Xufeng; Lu, Ping; Wang, Yanguang Tetrahedron, 2011 , vol. 67, # 43 p. 8338 - 8342

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Citation Number: 10

Abstract

Multicomponent reactions (MCRs) have emerged as a powerful and bond-forming efficient tool in organic, combinatorial, and medicinal chemistry. 5 Using this strategy, C2-founctionalizations of 1-substituted imidazoles have been successfully performed. 6 Considering the continued importance of the imidazole derivatives in both biological and chemical fields, new direct approaches remain highly valuable to the contemporary collection of synthetic methods.

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