Tetrahedron letters

A simple and efficient method for α-bromination of carbonyl compounds using N-bromosuccinimide in the presence of silica-supported sodium hydrogen sulfate as a …

B Das, K Venkateswarlu, G Mahender, I Mahender

Index: Das, Biswanath; Venkateswarlu, Katta; Mahender, Gurram; Mahender, Ibram Tetrahedron Letters, 2005 , vol. 46, # 17 p. 3041 - 3044

Full Text: HTML

Citation Number: 104

Abstract

α-Bromination of carbonyl compounds (cyclic and acyclic ketones, amides and β-ketoesters) has been achieved efficiently by treatment with N-bromosuccinimide (NBS) and catalyzed by silica-supported sodium hydrogen sulfate (NaHSO4· SiO2). The products were formed in high yields under mild reaction conditions and in short reaction times.

Related Articles:

Pneumocystis carinii pneumonia and mucosal candidiasis in previously healthy homosexual men: evidence of a new acquired cellular immunodeficiency

[Masuda, Naoyuki; Yamamoto, Osamu; Fujii, Masahiro; Ohgami, Tetsuro; Fujiyasu, Jiro; Kontani, Toru; Moritomo, Ayako; Orita, Masaya; Kurihara, Hiroyuki; Koga, Hironobu; Nakahara, Hideaki; Kageyama, Shunji; Ohta, Mitsuaki; Inoue, Hiroshi; Hatta, Toshifumi; Suzuki, Hiroshi; Sudo, Kenji; Shimizu, Yasuaki; Kodama, Eiichi; Matsuoka, Masao; Fujiwara, Masatoshi; Yokota, Tomoyuki; Shigeta, Shiro; Baba, Masanori Bioorganic and Medicinal Chemistry, 2004 , vol. 12, # 23 p. 6171 - 6182]

537. Elimination reactions. Part I. Acid-catalysed enolisation and substitution reactions of ketones

[Cardwell; Kilner Journal of the Chemical Society, 1951 , p. 2430,2440]

More Articles...