Towards the discovery of drug-like epigallocatechin gallate analogs as Hsp90 inhibitors

…, JJ Lee, TA Gasiewicz, EC Henry, DP Rotella

Index: Bhat, Rohit; Adam, Amna T.; Lee, Jungeun Jasmine; Gasiewicz, Thomas A.; Henry, Ellen C.; Rotella, David P. Bioorganic and Medicinal Chemistry Letters, 2014 , vol. 24, # 10 p. 2263 - 2266

Full Text: HTML

Citation Number: 5

Abstract

Abstract (−)-Epigallocatechin gallate (EGCG) is the major flavonoid of green tea and has been widely explored for a range of biological activities including anti-infective, anti- inflammatory, anti-cancer, and neuroprotection. Existing structure–activity data for EGCG has been largely limited to exploration of simple ethers and hydroxyl deletion. EGCG has poor drug-like properties because of multiple phenolic hydroxyl moieties and a ...