Conformationally constrained analogues of diacylglycerol. 29. Cells sort diacylglycerol-lactone chemical zip codes to produce diverse and selective biological …
…, RJ Surawski, PM Blumberg, VE Marquez
Index: Choi, Yongseok; Pu, Yongmei; Peach, Megan L.; Kang, Ji-Hye; Lewin, Nancy E.; Sigano, Dina M.; Garfield, Susan H.; Blumberg, Peter M.; Marquez, Victor E. Journal of Medicinal Chemistry, 2007 , vol. 50, # 15 p. 3465 - 3481
Full Text: HTML
Citation Number: 29
Abstract
Diacylglycerol-lactone (DAG-lactone) libraries generated by a solid-phase approach using IRORI technology produced a variety of unique biological activities. Subtle differences in chemical diversity in two areas of the molecule, the combination of which generates what we have termed “chemical zip codes”, are able to transform a relatively small chemical space into a larger universe of biological activities, as membrane-containing organelles within ...
Related Articles:
[Lee, Jeewoo; Kang, Ji-Hye; Lee, Sang-Yoon; Han, Kee-Chung; Torres, Christina M.; Bhattacharyya, Dipak K.; Blumberg, Peter M.; Marquez, Victor E. Journal of Medicinal Chemistry, 1999 , vol. 42, # 20 p. 4129 - 4139]
[Lee, Jeewoo; Kang, Ji-Hye; Lee, Sang-Yoon; Han, Kee-Chung; Torres, Christina M.; Bhattacharyya, Dipak K.; Blumberg, Peter M.; Marquez, Victor E. Journal of Medicinal Chemistry, 1999 , vol. 42, # 20 p. 4129 - 4139]
[Lee, Jeewoo; Kang, Ji-Hye; Lee, Sang-Yoon; Han, Kee-Chung; Torres, Christina M.; Bhattacharyya, Dipak K.; Blumberg, Peter M.; Marquez, Victor E. Journal of Medicinal Chemistry, 1999 , vol. 42, # 20 p. 4129 - 4139]