Synthesis and anti-arrhythmic activity of aminoguanidine derivatives

…, G Rablóczky, A Varró, G Somogy, M Kürthy…

Index: Erczi, I; Rabloczky, G; Varro, A; Somogy, G; Kuerthy, M; Body, I European Journal of Medicinal Chemistry, 1993 , vol. 28, # 3 p. 185 - 193

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Citation Number: 4

Abstract

Abstract A series of new aminoguanidine derivatives were synthesized and tested for anti- arrhythmic activity. The compounds selected were investigated on other test models. Finally, compound 13 1-(2, 6-dimethylphenyl)-4, 4-dimethyl-aminoguanidine-hydrochloride (B-GYKI- 38 233) was chosen for detailed study.