Application of Barluenga Boronic Coupling (BBC) to the Parallel Synthesis of Drug??like and Drug Fragment??like Molecules

S Nakagawa, KA Bainbridge, K Butcher, D Ellis…

Index: Nakagawa, Shoko; Bainbridge, Katie A.; Butcher, Ken; Ellis, Dave; Klute, Wolfgang; Ryckmans, Thomas ChemMedChem, 2012 , vol. 7, # 2 p. 233 - 236

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Citation Number: 9

Abstract

Library and array synthesis has proven an invaluable tool for medicinal chemists to quickly assess key structure–activity relationships against a biological target. The main requirements for the adoption of a given synthetic protocol are: 1) the availability of a diverse set of monomers (building blocks), 2) the reaction should be adapted to the preparation of drug-like molecules and thus should tolerate a wide range of functional groups, and 3) the ...