Synthesis and biological activity of anticancer ether lipids that are specifically released by phospholipase A2 in tumor tissue

…, SS Jensen, R Madsen, K Jørgensen

Index: Andresen, Thomas L.; Jensen, Simon S.; Madsen, Robert; Jorgensen, Kent Journal of Medicinal Chemistry, 2005 ,  vol. 48,  # 23  p. 7305 - 7314

Full Text: HTML

Citation Number: 31

Abstract

The clinical use of anticancer lipids is severely limited by their ability to cause lysis of red blood cells prohibiting intravenous injection. Novel delivery systems are therefore required in order to develop anticancer ether lipids (AELs) into clinically useful anticancer drugs. In a recent article (J. Med. Chem. 2004, 47, 1694) we showed that it is possible to construct liposome systems composed of masked AELs that are activated by secretory ...