272. Derivatives of 6-aminopenicillanic acid. Part I. α-Aminobenzylpenicillin and some related compounds

FP Doyle, GR Fosker, JHC Nayler…

Index: Doyle,F.P. et al. Journal of the Chemical Society, 1962 , p. 1440 - 1444            

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Citation Number: 36

Abstract

DESPITE the availability of several different penicillins 1 for the treatment of infections caused by Gram-positive bacteria, there remained a need for a broad-spectrum penicillin which would also be effective orally against Gram-negative organisms. D-4-Amino4 carboxybutylpenicillin (Cephalosporin N, Synnematin B) shows promising activity against certain Gram-negative organisms, particularly Salmortellae, but must be administered by ...