Studies on the total synthesis of CC-1065: preparation of a synthetic simplified 3-carbamoyl-1, 2-dihydro-3H-pyrrolo [3, 2-e] indole dimer/trimer/tetramer (CDPI dimer/ …

DL Boger, RS Coleman, BJ Invergo

Index: Boger, Dale L.; Coleman, Robert S.; Invergo, Benedict J. Journal of Organic Chemistry, 1987 ,  vol. 52,  # 8  p. 1521 - 1530

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Citation Number: 61

Abstract

Two synthetic preparations of 3-carbamoyl-l, 2-dihydro-3H-pyrrolo [3, 2-e] indole-7- carboxylic acid (2b, CDPI) and the investigation and development of methodology for the preparation of 3-carbamoyl-l, P-dihydro-3H-pyrrolol3, 2-e] indole dimer 3 (CDPI dimer) constituting the simplified and stable PDE-I dimer skeleton possessing the B-DNA minor groove complementary shape of the natural product CC-1065 are detailed. The extension ...