Phenanthrylalkanoic Acids I: Syntheses and Biological Activities of 1??Phenanthryl Derivatives

A Eirín, F Fernández, G Gómez, C López…

Index: Eirin; Fernandez; Gomez; Lopez; Santos; Calleja; De La Iglesia; Cano Archiv der Pharmazie, 1987 ,  vol. 320,  # 11  p. 1110 - 1118

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Citation Number: 8

Abstract

Abstract Reformatsky reactions between 3.4-dihydro-1 (2H)-phenanthrenone (5) and ethyl α- bromoacetate or propanoate yield several unsaturated esters which, upon aromatization followed by saponification, lead to the 1-phenanthrylacetic (1) and 2-(1-phenanthryl) propanoic (2) acids, whose analgesic and anti-inflammatory properties were measured and found comparable to those of Fenbufen.