Antioxidant activity of butane type lignans, secoisolariciresinol, dihydroguaiaretic acid, and 7, 7′-oxodihydroguaiaretic acid

…, T Masuda, T Sugahara, Y Kawaguchi…

Index: Yamauchi, Satoshi; Masuda, Toshiya; Sugahara, Takuya; Kawaguchi, Yuya; Ohuchi, Maya; Someya, Tatsushi; Akiyama, Jun; Tominaga, Shiori; Yamawaki, Manami; Kishida, Taro; Akiyama, Koichi; Maruyama, Masafumi Bioscience, Biotechnology and Biochemistry, 2008 ,  vol. 72,  # 11  p. 2981 - 2986

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Citation Number: 25

Abstract

The antioxidant activity of butane-type lignans was evaluated. Secoisolariciresinol (SECO) and dihydroguaiaretic acid (DGA) showed higher radical scavenging activity than that of 7, 7′-dioxodihydroguaiaretic acid (ODGA). SECO and DGA inhibited the oxidation of unsaturated fatty acid. Both enantiomers of DGA were also lipoxygenase inhibitors, but neither enantiomer of SECO inhibited the lipoxygenase activity.