Selective bromination of 4-chloro-1-indanone and synthesis of (4-chloro-2, 3-dihydro-1H-indene-2-yl) methanamine

S Jasouri, J Khalafy, M Badali, M Piltan

Index: Jasouri; Khalafy; Badali; Piltan South African Journal of Chemistry, 2010 ,  vol. 63, p. 83 - 87

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Citation Number: 2

Abstract

ABSTRACT The synthesis of 4-chloro-1-indanone in four steps from 2-chlorobenzaldehyde was investigated. Bromination of this compound under various conditions occurred in the cyclopentanone ring, producing mono- and dibromo derivatives. Cyanation of 2-bromo-4-chloro-1-indanone followed by reduction gave (4-chloro-2, 3-dihydro-1H-indene-2-yl)methanamine in quantitative yield. ... KEYWORDS Indanone, bromination, cyanation, reduction, GABAB receptors.