Total synthesis of (±)− jolkinolide A, B, and E utilizing a new mild esterification followsd by intramolecular Wittig-Horner reaction

S Katsumura, A Kimura, S Isoe

Index: Katsumura, Shigeo; Kimura, Akihiko; Isoe, Sachihiko Tetrahedron, 1989 , vol. 45, # 5 p. 1337 - 1346

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Citation Number: 38

Abstract

Jolkinolide A, B, and E were efficiently synthesized from 9-methoxy-carbonyl-4, 4, 10- trimethyl-Δ6-8-octalone 8 through Δ8 (14)-podocalpen-13-one 12. A new synthetic method of γ-ylidenbutenolide consisting of mild esterification and the succeeding intramolecular Wittig-Horner reaction of α-diketone was developed.