Ruthenium− porphyrin conjugates with cytotoxic and phototoxic antitumor activity
T Gianferrara, A Bergamo, I Bratsos…
Index: Gianferrara, Teresa; Bergamo, Alberta; Bratsos, Ioannis; Milani, Barbara; Spagnul, Cinzia; Sava, Gianni; Alessio, Enzo Journal of Medicinal Chemistry, 2010 , vol. 53, # 12 p. 4678 - 4690
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Citation Number: 78
Abstract
We report here two novel “extended-arms” porphyrins, TetbpyPP and TedabpyPP, in which four peripheral bpy fragments are connected to the meso positions of the macrocycle through flexible linkers of different length and hydrophilicity. We describe also the new, water-soluble, tetracationic conjugate [TedabpyPP {Ru ([9] aneS3) Cl} 4][Cl] 4 (6). Compound 6 belongs to the series of cationic Ru− porphyrin conjugates 1− 5, each ...
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