Dicyanostilbene-derived two-photon fluorescence probe for free zinc ions in live cells and tissues with a large two-photon action cross section

C Huang, J Qu, J Qi, M Yan, G Xu

Index: Huang, Chibao; Qu, Junle; Qi, Jing; Yan, Meng; Xu, Gaixia Organic Letters, 2011 , vol. 13, # 6 p. 1462 - 1465

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Citation Number: 27

Abstract

A novel two-photon fluorescence probe for Zn2+ derived from dicyanostilbene as a two- photon fluorophore and 4-(pyridine-2-ylmethyl) piperazine as a novel Zn2+ ligand was developed. The probe shows a 72.5-fold fluorescence enhancement in response to Zn2+, a large two-photon action cross-section (580 GM), a noncytotoxic effect, and pH insensitivity in the biologically relevant range, and its dissociation constant (K dTP) is 0.52±0.01 μM. The ...