Design and validation of bicyclic iminopyrimidinones as beta amyloid cleaving enzyme-1 (BACE1) inhibitors: conformational constraint to favor a bioactive …

M Mandal, Z Zhu, JN Cumming, X Liu…

Index: Journal of Medicinal Chemistry, , vol. 55, # 21 p. 9331 - 9345

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Citation Number: 34

Abstract

... Journal of Medicinal ... Department of Medicinal Chemistry, ‡ Department of ... the amyloid hypothesis based on discoveries using biochemistry, human genetics, and pathology,(2) vigorous research in both academia and industry was undertaken to address this unmet medical need ...