Chemistry Letters

TOTAL SYNTHESIS OF NEOMETHYNOLIDE

J Inanaga, Y Kawanami, M Yamaguchi

Index: Inanaga, Junji; Kawanami, Yasuhiro; Yamaguchi, Masaru Chemistry Letters, 1981 , p. 1415 - 1418

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Citation Number: 12

Abstract

(+)-Neomethynolide, the aglycone of a twelve-membered ring macrolide, neomethymycin, was totally synthesized via its 8, 9-didehydro derivative. The synthesis also established the stereochemistry of neomethynolide at C-10, C-11, C-12, and 8, 9-double bond which had remained unproved.