The Synthesis of (S)-5-Fluoro-1-(2-fluorophenyl)-3-(piperidin-3-ylmethoxy)-1 H-indazole, a Norepinephrine/Serotonin Reuptake Inhibitor for the Treatment of …

J Magano, M Waldo, D Greene…

Index: Organic Process Research and Development, , vol. 12, # 5 p. 877 - 883

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Abstract

... 16 could be resolved via a classical resolution or through an enzymatic process.(17) Since ... in ethanol, prepared by adding acetyl chloride to cold ethanol.(19) This procedure afforded HCl ... The organic layer was washed with water (2 × 1 L), saturated, aqueous NaHCO 3 solution ...

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