On the racemisation of aspartic anhydride during its preparation

…, G Deguest, L Bischoff, C Fruit, F Marsais

Index: Buron, Frederic; Deguest, Geoffrey; Bischoff, Laurent; Fruit, Corinne; Marsais, Francis Tetrahedron Asymmetry, 2007 , vol. 18, # 13 p. 1625 - 1627

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Citation Number: 6

Abstract

Due to the possible differentiation of both carboxyl groups, N-protected aspartic anhydride is a useful starting material in synthesis. However, most methods published in the literature for its formation lead to partial racemisation, which is generally not mentioned. Herein we report a comparison between the main methods published, with accurate measurements of the enantiomeric purity of this compound.