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A novel synthesis of S 6-cyanoethyl-2′-deoxy-6-thioguanosine and its incorporation into triple helix forming oligonucleotides

TS Rao, K Jayaraman, RH Durland, GR Revankar

Index: Sudhakar Rao; Jayaraman; Durland; Revankar Tetrahedron Letters, 1992 , vol. 33, # 50 p. 7651 - 7654

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Citation Number: 17

Abstract

Abstract A simple and expeditious synthesis of S 6-cyanoethyl-2′-deoxy-6-thioguanosine from 2′-deoxyguanosine has been accomplished in good yield and incorporated into several triple helix forming oligonucleotides using the solid-phase phosphoramidite chemistry.