Journal of medicinal chemistry

New antihypertensive cannabinoids

HE Zaugg, J Kyncl

Index: Zaugg, Harold E.; Kyncl, Jaroslav Journal of Medicinal Chemistry, 1983 , vol. 26, # 2 p. 214 - 217

Full Text: HTML

Citation Number: 16

Abstract

A number of azacannabinoids containing hydroxyacyl and aminoacetyl substituents on the nitrogen atom were synthesized. The hydroxyacetyl and y-hydroxybutyryl derivatives (4a and 7b, respectively) were potent antihypertensive agents (minimum effective dose, 3-5 mg/kg, orally) of the same order of activity as the highly CNS-active N-propargyl derivatives Ia and Ib. Furthermore, 4a showed weak stimulant properties at hypotensive dose levels, ...