Cleavage of α-dicarbonyl compounds by terpene hydroperoxide

R Nagamatsu, S Mitsuhashi, K Shigetomi…

Index: Nagamatsu, Ryu-Ichiro; Mitsuhashi, Shinya; Shigetomi, Kengo; Ubukata, Makoto Bioscience, Biotechnology and Biochemistry, 2012 , vol. 76, # 10 p. 1904 - 1908

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Citation Number: 4

Abstract

Abstract The highly reactive α-dicarbonyl compounds, glyoxal, methylglyoxal (MGO), and 3- deoxyglucosone, react with the amino groups of proteins to form advanced glycation end- products (AGEs) which have been implicated in diabetic complications, aging, and Alzheimer's disease. We found that a test sample of terpinen-4-ol (T4) containing hydroperoxides showed cleaving activity toward an α-dicarbonyl compound, but that the ...