Asian Journal of Chemistry

Prediction of Chemical Stability of Ibuprofen in Solution: An Accelerated Aging Study

AS Ijaz, G Murtaza, I Hussain

Index: Atiq-Ur-Rehman; Ijaz, Abdul Subhan; Murtaza, Ghulam; Hussain, Izhar Asian Journal of Chemistry, 2012 , vol. 24, # 11 p. 4939 - 4943

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Abstract

Abstract Ibuprofen, propionic acid derivative, was subjected to different temperature (20, 30, 37, 40, 50 and 60 ºC) and pH (3, 4, 5, 6, 7 and 8) conditions. The samples were assayed at time intervals 0, 12, 24, 36 and 48 h by taking their UV/VIS absorbance at wavelengths 272 and 258 nm. Ratios of absorbance at any time were taken as a parameter, proportional to the concentration of intact substance. The degradation processes were assumed to follow ...

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